The former First Lady stunned the star-studded audience as she walked onto the stage at the Staples Center in Los Angeles on Sunday night.
Fans were screaming and blowing kisses to Michelle as she smiled before saying 'We've got a show to do!' and began laughing with her co-presenters.
Michelle absolutely sparkled as she stood alongside Lady Gaga, Jennifer Lopez, Jada Pinkett Smith, and Keys to discuss how music has always helped her tell her story.
'From the Motown records that I wore out on the Southside, to the Who Run The World songs that fueled me through this last decade, music has always helped me tell my story and I know that's true for everyone here,' Michelle said, throwing in a quick tribute to Beyonce as the audience went wild.
'Music helps us share ourselves, our dignity and sorrows, our hopes our joys,' she continued.
'It allows us to hear one another - to invite each other in. Music shows us that all of it matters...every story within every voice, every note within every song.'
Michelle walked onto the stage in a dazzling Sachin & Babi outfit that featured a billowing silver blouse with matching slacks and a sparkling belt wrapped above her hips.